QCM Flow Cell

The quartz crystal microbalance (QCM) technique under electrochemical frequency is very useful to determine many compounds such as metal proteins, metal ions and thiol-conjugated oligonucleotides.

The Resonance frequency of quartz changes when material attaches to the electrode’s surface. This product is capable of super-micro quantitative analysis by using this unique behavior.

Catalog No. Description Components
011121 QCM Flow cell kit Acrylic Flow Cell
Teflon tube
Dynaseal PEEK (2)
Fixing Screw (2)
Silicon O-Ring (2)
Flow Cell Holder
Pt counter electrode
Optional Products
012167 RE-1B Reference electrode (Ag/AgCl)
012171 RE-7 Non Aqueous reference electrode (Ag/Ag+)
QCM flow cell kit -- Stability of base line IDA Electrode Connecting Cable kit
solution: PBS with 2 mM Dithiodipropionic acid
a: stationary state
Flow rate: b:85, c:110, d:140, e:160, f:190 µl/minBaseline is stable enough as shown in figure.
Above figure shows result of change in frequency with time by adding :
avidin (2 mg/ml), ethanolamine (5 mM), BSA in PBS (1%),
Biotin-Allo A lectin (0.05 mg/ml, in 1% BSA),
galactose-carrying polymer (1 mg/ml, in 1% BSA), PBS

Thickness of 10 MHz quartz is 0.16 mm. Accelerating the oscillation frequency means to make the quartz thinner and delicate. Resolution and easiness to care for should be taken into the consideration. We can offer two surface conditions of quartz – Polished and Unpolished. Polished one has a 100 Å thickness of gold layer on a titanium adhesive layer. We would recommend the unpolished quartz if there is a possibility that the titanium layer might effect on your experiment. We would like you to note that the gold layer on the unpolished quartz peels off easier than the polished one because it does not have adhesive layer.

Catalog No. Description qty Frequency
010226 Quartz crystal Au 5 7.995 MHz
013447 Quartz crystal Pt 3
012772 Blank Crystal with holder 5

This cell even can be used in two ways, with the choose of PEEK Cell or Acrylic Flow Cell.

  • Acrylic Flow Cell, for QCM Flow Mode
  • PEEK Cell, for EQCM Mode
QCM_photo Structure_QCM

Using physical absorption such as antigen-antibody reaction on a solid surface

EQCM_photo Structure_EQCM

Using electrochemical absorption

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